
Subcutaneous Ketamine Therapy: How It Works and What We Offer
What subcutaneous ketamine therapy involves, how it differs from IV and at-home products, and why medical supervision matters.
What subcutaneous ketamine therapy involves
At our clinic, ketamine is administered subcutaneously — a small injection given under the skin — at a dose calculated for you by the supervising clinician before the session begins. The clinical team monitors you continuously as the effects develop and settle.
Sessions take place in a monitored treatment room. A clinician places monitoring equipment, stays attentive throughout, and checks your recovery before you leave with the ride you arranged. A typical visit lasts under two hours, door to door.
How our treatment compares with intranasal esketamine
Esketamine is a nasal spray derived from ketamine. The subcutaneous racemic ketamine we administer is a compounded medication, and no compounded medication is FDA-approved for any use. It is not FDA-approved for mood or pain conditions, nor for the subcutaneous route of administration.
Both approaches require in-person supervision. They differ in how the medication is given and how precisely dosing can be controlled. If you are weighing one against the other, we can walk through those differences during your evaluation.
How in-clinic treatment compares with at-home ketamine products
A third category has grown quickly: compounded ketamine lozenges, tablets, or nasal sprays — often prescribed online and taken at home without in-person monitoring. The FDA has warned patients and health care providers about potential risks associated with compounded ketamine products, particularly when they are used without adequate safeguards.
Taking ketamine at home without in-person monitoring is not equivalent to treatment in a monitored clinic, and it is not the same as an intranasal product. Dosing precision, screening, and what happens if something goes wrong all differ. We believe a monitored setting is the responsible standard, and it is the standard we hold ourselves to.
What our clinic offers
Our clinic administers subcutaneous racemic ketamine — a small injection under the skin — for psychiatric conditions, prescribed only after a full medical evaluation. That evaluation can happen in person at the clinic or by telehealth, whichever suits you; the treatment itself never happens anywhere but the clinic. We do not offer IV infusions, intranasal esketamine, or at-home ketamine programs.
What will not change is the standard around the modality: physician oversight, careful screening, monitoring during every session, and planned follow-up afterward.
Why supervision matters
Ketamine's short-term effects — dissociation, nausea, dizziness, and temporary blood-pressure changes — are manageable in a monitored setting and meaningfully riskier without one. Supervision also means a qualified person is watching for the less common problems and can respond immediately.
After any session you will need a responsible adult to drive you home, and you should not drive until the following day. These rules exist for your safety, and they apply to every patient, every time.
In person or by telehealth
You can be seen both ways. Consultations, planning conversations, and follow-up visits happen in person at our Wesley Chapel clinic or by telehealth — whichever works better for you.
Ketamine itself is always administered in person, at the clinic, with a clinician monitoring you throughout. We do not prescribe ketamine for use at home.
Telehealth visits require you to be physically located in Florida at the time of the visit.
How telehealth works here
- Telehealth is available to patients who are physically located in Florida, and the clinicians providing that care hold active Florida licenses.
- Your location is confirmed at the start of every telehealth visit. If you are not in Florida, the visit does not go ahead.
- Ketamine is never prescribed for you to take at home. It is administered only at our clinic, in person, with a clinician monitoring you throughout — a telehealth visit does not change that.
- You are seen in person before any treatment session, because every session happens at the clinic.
- A telehealth visit never guarantees that treatment will be offered, any more than an in-person evaluation does.
- Telehealth is not for emergencies. If you are in crisis or having thoughts of self-harm, call or text 988, or call 911.
Common questions
The ketamine used here is compounded by a licensed outsourcing facility and is not FDA-approved. No compounded medication is FDA-approved for any use, for depression, anxiety, PTSD, pain, or anything else. We are glad to explain what that means before you decide anything.
Intranasal esketamine is given as a nasal spray under a restricted program. Our treatment is racemic ketamine given subcutaneously — a small injection under the skin — with in-person monitoring. Both require in-person monitoring; which one fits depends on your diagnosis, history, and coverage, and it is worth discussing during evaluation.
At-home services generally provide compounded lozenges or tablets used without in-person monitoring. The FDA has cautioned about risks tied to compounded ketamine in those circumstances. Our treatment happens in the clinic, with monitoring during and after every session.
Plan for roughly 90 minutes to two hours at the clinic, including preparation, the treatment itself, and monitored recovery before your ride takes you home.
We administer racemic ketamine subcutaneously — a small injection under the skin — in a monitored clinical setting. We do not offer IV infusions, intranasal esketamine, or at-home ketamine. Whether this treatment fits your situation is determined during your evaluation.
Sources & further reading
- FDA warns patients and health care providers about potential risks associated with compounded ketamine products — U.S. Food and Drug Administration. Accessed 2026-07-23.
Links point to external organizations. Clear Ketamine Therapy does not control their content.
Reviewed by Editorial team. Last reviewed 2026-07-23. Educational information only — not medical advice or a substitute for care from your own clinicians.
Keep reading
- Ketamine Therapy TampaPhysician-supervised ketamine therapy for adults across Tampa, Florida — what it is, who it may help, and how to start. Our clinic is in nearby Wesley Chapel.
- What to ExpectA plain-language walkthrough of the full treatment process at our Wesley Chapel clinic — the evaluation, the sessions themselves, and the follow-up — including the parts that vary from person to person.
- How Ketamine WorksWhat researchers know — and are still testing — about how ketamine affects the brain, glutamate signaling, and mood.
- IV vs. At-Home KetamineAt-home ketamine programs are convenient, but the FDA has warned about compounded ketamine used outside monitored settings. Here are the real trade-offs.
- ResearchHow we read ketamine research: what is established, what is emerging, and how primary sources shape our clinical policies.
Talk with our clinical team
A consultation is a conversation, not a commitment. Ask questions, share what you are comfortable sharing, and learn whether ketamine therapy may be worth considering for you.
Not for emergencies — call or text 988 or 911 if you are in crisis.